A novel serine protease inhibitor from the venom of Vespa bicolor Fabricius.
作者： Xinbo Yang , Yakun Wang , Zekuan Lu , Lei Zhai , Juguo Jiang
DOI: 10.1016/J.CBPB.2009.02.010
关键词:
摘要: Hornets possess highly toxic venoms, which are rich in toxin, enzymes and biologically active peptides. Many bioactive substances have been identified from wasp venoms but only a few serine protease inhibitors two kinds of venoms. In this work, inhibitor named bicolin was purified characterized the venom wasp, Vespa bicolor Fabricius. The precursor encoding cloned cDNA library venomous glands. It is cysteine-rich small protein containing 54 amino acid residues including 6 half-cysteines. peptide homologous to isolated Anoplius samariensis Pimpla hypochondriaca. Bicolin showed inhibitory ability against trypsin thrombin.
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