Non-human primate models of hormonal contraception and HIV.

摘要: Problem Recent concerns that hormonal contraception (HC) may increase risk of HIV acquisition has led to keen interest in using non-human primates (NHP) understand the underlying mechanism and magnitude risk. This is, part, because some experiments which would be difficult or logistically impossible women are more easily conducted NHP. Method study NHP models can inform pathogenesis research identify evaluate biomedical preventions treatments for HIV/AIDS. Widely used species include rhesus, pigtail, cynomolgous macaques. Results This paper reviews past, current proposed NHP around intersection HC. Conclusion NHP lead identification hormonally regulated biomarkers correlate with HIV-acquisition risk, a ranking existing next-generation HC along an profile, new HIV.