Urease and the acidosis of urinary intestinal diversion.

摘要: Previous investigators have suggested that urinary tract infections with urea-splitting organisms may be a primary etiologic factor in the acidosis which is seen after diversion. This study employs model small intestinal segments are perfused an artificial urine solution over three hour period. Urease then added order to determine its effect on acid-base balance and net electrolyte transport. created no significant increase acid load (delta HCO3- = -7.5 +/- 2.2 for controls vs. -8.7 2.9 urease group), but did osmolality of contents resulted 24% free water loss (p .037). Analysis sodium chloride movement following addition perfusate suggests both ammonium bicarbonate absorbed by segment. Thus any resulting from increased absorption appears offset concomitant absorption. The azotemia diversion primarily result urea absorption, partially not significantly urease.