Vitamin E modulates apoptosis and c-jun N-terminal kinase activation in ovarian torsion–detorsion injury
作者： Melike Sapmaz-Metin , Yeter Topcu-Tarladacalisir , Yesim Hulya Uz , Mustafa Inan , Imran Kurt Omurlu
DOI: 10.1016/J.YEXMP.2013.07.007
关键词:
摘要: The aim of this study was to evaluate the role vitamin E in follicular degeneration and assess histopathological biochemical changes following ischemia-reperfusion (IR) injury rat ovaries. Twenty-eight Wistar albino rats were randomly divided into four groups: sham, 4h torsion, 24h detorsion, a group. Thirty minutes before single dose 200mg/kg administered intraperitoneally. ovarian histology score determined, serum levels malondialdehyde (MDA) myeloperoxidase (MPO) measured. apoptosis granulosa cells phospho-c-jun N-terminal kinase (p-JNK) phospho-p38 (p-p38) immunoreactivities these determined. MDA MPO significantly increased torsion detorsion groups. Hemorrhage, edema, congestion also apparent In addition, apoptotic index immunoreactivity p-JNK highest group, which showed marked degeneration. However, p-p38 activity not affected by torsion-detorsion (TD) induction. Vitamin ameliorated TD-induced histological alterations. It decreased MPO, reduced ovaries, numbers cells. conclusion, data indicate that attenuated inhibiting reducing
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