Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells.
作者： Heng-Yu Fan , Zhilin Liu , Nicola Cahill , JoAnne S. Richards
DOI: 10.1210/ME.2008-0095
关键词:
摘要: … and thereby enhances granulosa cell differentiation in culture. To identify the physiological role … To selectively disrupt Pten expression in granulosa cells, Pten fl/fl mice were mated with …
oup.com
endojournals.org参考文章(35)
JEFFREY W. CLEMENS, K. MORRIS JAQUELINE, TAMARA ALLISTON, JOANNE S. RICHARDS, SUSAN L. FITZPATRICK, JEAN SIROIS, Ovarian cell differentiation: a cascade of multiple hormones, cellular signals, and regulated genes. Recent Progress in Hormone Research. ,vol. 50, pp. 223- 254 ,(1995) , 10.1016/B978-0-12-571150-0.50014-7
Philippe Soriano, Generalized lacZ expression with the ROSA26 Cre reporter strain Nature Genetics. ,vol. 21, pp. 70- 71 ,(1999) , 10.1038/5007
Kelly L. AUER, Jong-Sung PARK, Prem SETH, Robert J. COFFEY, Gretchen DARLINGTON, Arie ABO, Martin McMAHON, Ronald A. DePINHO, Paul B. FISHER, Paul DENT, Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice. Biochemical Journal. ,vol. 336, pp. 551- 560 ,(1998) , 10.1042/BJ3360551
Rebecca L. Robker, JoAnne S. Richards, Hormone-Induced Proliferation and Differentiation of Granulosa Cells: A Coordinated Balance of the Cell Cycle Regulators Cyclin D2 and p27Kip1 Molecular Endocrinology. ,vol. 12, pp. 924- 940 ,(1998) , 10.1210/MEND.12.7.0138
Ralf Lesche, Matthias Groszer, Jing Gao, Ying Wang, Albee Messing, Hong Sun, Xin Liu, Hong Wu, Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis. ,vol. 32, pp. 148- 149 ,(2002) , 10.1002/GENE.10036
L. C. Cantley, B. G. Neel, New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 4240- 4245 ,(1999) , 10.1073/PNAS.96.8.4240
Maki Goto, Akira Iwase, Hisao Ando, Shozo Kurotsuchi, Toko Harata, Fumitaka Kikkawa, PTEN and Akt expression during growth of human ovarian follicles Journal of Assisted Reproduction and Genetics. ,vol. 24, pp. 541- 546 ,(2007) , 10.1007/S10815-007-9156-3
Surbhi Gupta, Antoine R. Ramjaun, Paula Haiko, Yihua Wang, Patricia H. Warne, Barbara Nicke, Emma Nye, Gordon Stamp, Kari Alitalo, Julian Downward, Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice Cell. ,vol. 129, pp. 957- 968 ,(2007) , 10.1016/J.CELL.2007.03.051
P. Reddy, L. Liu, D. Adhikari, K. Jagarlamudi, S. Rajareddy, Y. Shen, C. Du, W. Tang, T. Ha ma la inen, S. L. Peng, Z.-J. Lan, A. J. Cooney, I. Huhtaniemi, K. Liu, Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool Science. ,vol. 319, pp. 611- 613 ,(2008) , 10.1126/SCIENCE.1152257
Pascal Froment, Martine Bontoux, Claudine Pisselet, Philippe Monget, Joëlle Dupont, PTEN expression in ovine granulosa cells increases during terminal follicular growth FEBS Letters. ,vol. 579, pp. 2376- 2382 ,(2005) , 10.1016/J.FEBSLET.2005.03.036