Adaptations to Climate in Candidate Genes for Common Metabolic Disorders
作者： Angela M Hancock , David B Witonsky , Adam S Gordon , Gidon Eshel , Jonathan K Pritchard
DOI: 10.1371/JOURNAL.PGEN.0040032
关键词:
摘要: Evolutionary pressures due to variation in climate play an important role shaping phenotypic among and within species have been shown influence phenotypes such as body shape size humans. Genes involved energy metabolism are likely be central heat cold tolerance. To test the hypothesis that shaped genes humans, we used a bioinformatics approach based on network theory select 82 candidate for common metabolic disorders. We genotyped 873 tag SNPs these 54 worldwide populations (including 52 Human Genome Diversity Project panel) found correlations with variables using rank correlation analysis newly developed method termed Bayesian geographic analysis. In addition, 210 carefully matched control provide empirical null distribution spatial patterns of allele frequency population history alone. For nearly all variables, excess genic tail distributions statistics compared SNPs, implying group show signals spatially varying selection. Among our strongest were several (e.g., LEPR R109K, FABP2 A54T) had previously associated directly related Since may correlated other aspects environmental variation, it is possible some detected reflect selective than climate. Nevertheless, results consistent idea has pressure acting
core.ac.uk
stanford.edu
paperity.org参考文章(102)
I. Barroso, M. Gurnell, V. E. F. Crowley, M. Agostini, J. W. Schwabe, M. A. Soos, G. LI Maslen, T. D. M. Williams, H. Lewis, A. J. Schafer, V. K. K. Chatterjee, S. O'Rahilly, Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension Nature. ,vol. 402, pp. 880- 883 ,(1999) , 10.1038/47254
Janet M. Storey, Kenneth B. Storey, Cold Hardiness and Freeze Tolerance John Wiley & Sons, Inc.. pp. 473- 503 ,(2005) , 10.1002/047167558X.CH17
O. Lao, J. M. de Gruijter, K. van Duijn, A. Navarro, M. Kayser, Signatures of positive selection in genes associated with human skin pigmentation as revealed from analyses of single nucleotide polymorphisms. Annals of Human Genetics. ,vol. 71, pp. 354- 369 ,(2007) , 10.1111/J.1469-1809.2006.00341.X
D. F. Roberts, Climate and human variability Addison-Wesley. ,(1973)
N. Bradshaw, C. Brewer, G. Brice, B. Bullman, J. Campbell, B. Castle, R. Cetnarsryj, C. Chapman, C. Chu, N. Coates, T. Cole, R. Davidson, A. Donaldson, H. Dorkins, F. Douglas, D. Eccles, R. Eeles, F. Elmslie, D. G. Evans, S. Goff, S. Goodman, D. Goudie, J. Gray, L. Greenhalgh, H. Gregory, S. V. Hodgson, T. Homfray, R. S. Houlston, L. Izatt, L. Jackson, L. Jeffers, V. Johnson-Roffey, F. Kavalier, C. Kirk, F. Lalloo, C. Langman, I. Locke, M. Longmuir, J. Mackay, A. Magee, S. Mansour, Z. Miedzybrodzka, J. Miller, P. Morrison, V. Murday, J. Paterson, G. Pichert, M. Porteous, N. Rahman, M. Rogers, S. Rowe, S. Shanley, A. Saggar, G. Scott, L. Side, L. Snadden, M. Steel, M. Thomas, S. Thomas, M. I. McCarthy, A. T. Hattersley, , E. Zeggini, M. N. Weedon, C. M. Lindgren, T. M. Frayling, K. S. Elliott, H. Lango, N. J. Timpson, J. R. B. Perry, N. W. Rayner, R. M. Freathy, J. C. Barrett, B. Shields, A. P. Morris, S. Ellard, C. J. Groves, L. W. Harries, J. L. Marchini, K. R. Owen, B. Knight, L. R. Cardon, M. Walker, G. A. Hitman, A. D. Morris, A. S. F. Doney, P. R. Burton, D. G. Clayton, N. Craddock, P. Deloukas, A. Duncanson, D. P. Kwiatkowski, W. H. Ouwehand, N. J. Samani, J. A. Todd, P. Donnelly, D. Davison, D. Easton, D. Evans, H.-T. Leung, C. C. A. Spencer, M. D. Tobin, A. P. Attwood, J. P. Boorman, B. Cant, U. Everson, J. M. Hussey, J. D. Jolley, A. S. Knight, K. Koch, E. Meech, S. Nutland, C. V. Prowse, H. E. Stevens, N. C. Taylor, G. R. Walters, N. M. Walker, N. A. Watkins, T. Winzer, R. W. Jones, W. L. McArdle, S. M. Ring, D. P. Strachan, M. Pembrey, G. Breen, D. St. Clair, S. Caesar, K. Gordon-Smith, L. Jones, C. Fraser, E. K. Green, D. Grozeva, M. L. Hamshere, P. A. Holmans, I. R. Jones, G. Kirov, V. Moskvina, I. Nikolov, M. C. O'Donovan, M. J. Owen, D. A. Collier, A. Elkin, A. Farmer, R. Williamson, P. McGuffin, A. H. Young, I. N. Ferrier, S. G. Ball, A. J. Balmforth, J. H. Barrett, D. T. Bishop, M. M. Iles, A. Maqbool, N. Yuldasheva, A. S. Hall, P. S. Braund, R. J. Dixon, M. Mangino, S. Stevens, J. R. Thompson, F. Bredin, M. Tremelling, M. Parkes, H. Drummond, C. W. Lees, E. R. Nimmo, J. Satsangi, S. A. Fisher, A. Forbes, C. M. Lewis, C. M. Onnie, N. J. Prescott, J. Sanderson, C. G. Mathew, J. Barbour, M. K. Mohiuddin, C. E. Todhunter, J. C. Mansfield, T. Ahmad, F. R. Cummings, D. P. Jewell, J. Webster, M. J. Brown, G. M. Lathrop, J. Connell, A. Dominiczak, C. A. Braga Marcano, B. Burke, R. Dobson, J. Gungadoo, K. L. Lee, P. B. Munroe, S. J. Newhouse, A. Onipinla, C. Wallace, M. Xue, M. Caulfield, M. Farrall, A. Barton, I. N. Bruce, H. Donovan, S. Eyre, P. D. Gilbert, S. L. Hider, A. M. Hinks, S. L. John, C. Potter, A. J. Silman, D. P. M. Symmons, W. Thomson, J. Worthington, D. B. Dunger, B. Widmer, M. Newport, G. Sirugo, E. Lyons, F. Vannberg, A. V. S. Hill, L. A. Bradbury, C. Farrar, J. J. Pointon, P. Wordsworth, M. A. Brown, J. A. Franklyn, J. M. Heward, M. J. Simmonds, S. C. L. Gough, S. Seal, M. R. Stratton, N. Rahman, M. Ban, A. Goris, S. J. Sawcer, A. Compston, D. Conway, M. Jallow, K. A. Rockett, S. J. Bumpstead, A. Chaney, K. Downes, M. J. R. Ghori, R. Gwilliam, S. E. Hunt, M. Inouye, A. Keniry, E. King, R. McGinnis, S. Potter, R. Ravindrarajah, P. Whittaker, C. Widden, D. Withers, N. J. Cardin, T. Ferreira, J. Pereira-Gale, I. B. Hallgrimsdottir, B. N. Howie, Z. Su, Y. Y. Teo, D. Vukcevic, D. Bentley, A. Compston, N. J. Ouwehand, M. R. Samani, J. D. Isaacs, A. W. Morgan, G. D. Wilson, A. Ardern-Jones, J. Berg, A. Brady, Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes Science. ,vol. 316, pp. 1336- 1341 ,(2007) , 10.1126/SCIENCE.1142364
Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Andrei Manolescu, Jesus Sainz, Agnar Helgason, Hreinn Stefansson, Valur Emilsson, Anna Helgadottir, Unnur Styrkarsdottir, Kristinn P Magnusson, G Bragi Walters, Ebba Palsdottir, Thorbjorg Jonsdottir, Thorunn Gudmundsdottir, Arnaldur Gylfason, Jona Saemundsdottir, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Vilmundur Gudnason, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Kari Stefansson, Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nature Genetics. ,vol. 38, pp. 320- 323 ,(2006) , 10.1038/NG1732
A Latitudinal Cline in a Drosophila Clock Gene Proceedings of The Royal Society B: Biological Sciences. ,vol. 250, pp. 43- 49 ,(1992) , 10.1098/RSPB.1992.0128
Vanina Guernier, Michael E Hochberg, Jean-François Guégan, None, Ecology drives the worldwide distribution of human diseases. PLOS Biology. ,vol. 2, pp. 0740- 0746 ,(2004) , 10.1371/JOURNAL.PBIO.0020141
M Serrato, A J Marian, A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease. Journal of Clinical Investigation. ,vol. 96, pp. 3005- 3008 ,(1995) , 10.1172/JCI118373
Keiko Sato, Mitsuru Emi, Yoichi Ezura, Yuko Fujita, Daisuke Takada, Tomoaki Ishigami, Satoshi Umemura, Yunpei Xin, Lily L Wu, Stacey Larrinaga-Shum, Susan H Stephenson, Steven C Hunt, Paul N Hopkins, None, Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred Journal of Human Genetics. ,vol. 49, pp. 29- 34 ,(2004) , 10.1007/S10038-003-0103-6