Simulation of gastric lipolysis and prediction of felodipine release from a matrix tablet in the fed stomach
作者： A. Diakidou , M. Vertzoni , B. Abrahamsson , J. Dressman , C. Reppas
DOI: 10.1016/J.EJPS.2009.02.003
关键词:
摘要: The importance of intragastric lipolysis to felodipine release from a hydrophilic, extended tablet in the fed stomach was assessed USP II apparatus with fixed on steel wire above paddle. medium, homogenized long-life milk, gradually digested shots acidic solutions pepsin over course experiment absence and presence biorelevant concentrations lipase that similar human gastric lipase. Percentage erosion at specific times same media measured separate experiments. data were compared published for healthy adults. In all cases, occurred under sink conditions. Lipase facilitated eroded polymer, bringing profile closer vivo data. Likewise, relationship between amount released reflected only when added medium. It concluded modelling is necessary order simulate tablets stomach.
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Eleftheria Nicolaides, Moira Symillides, Jennifer B. Dressman, Christos Reppas, Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration. Pharmaceutical Research. ,vol. 18, pp. 380- 388 ,(2001) , 10.1023/A:1011071401306
P. Walstra, R. Jenness, Dairy chemistry and physics ,(1984)
Kilian Kelly, Bridget O'Mahony, Blythe Lindsay, Tamara Jones, Tim J. Grattan, Amin Rostami‐Hodjegan, Howard N. E. Stevens, Clive G. Wilson, Comparison of rates of disintegration, gastric emptying, and drug absorption following administration of a new and a conventional paracetamol formulation, using γ scintigraphy Pharmaceutical Research. ,vol. 20, pp. 1668- 1673 ,(2003) , 10.1023/A:1026155822121
Bertil Abrahamsson, Magne Alpsten, Morgan Hugosson, Ulf E. Jonsson, Mats Sundgren, Agneta Svenheden, Jukka Tölli, Absorption, gastrointestinal transit, and tablet erosion of felodipine extended-release (ER) tablets Pharmaceutical Research. ,vol. 10, pp. 709- 714 ,(1993) , 10.1023/A:1018959732744
Jennifer B. Dressman, Rosemary R. Berardi, Lambros C. Dermentzoglou, Tanya L. Russell, Stephen P. Schmaltz, Jeffrey L. Barnett, Kathleen M. Jarvenpaa, Upper gastrointestinal (GI) pH in young, healthy men and women. Pharmaceutical Research. ,vol. 7, pp. 756- 761 ,(1990) , 10.1023/A:1015827908309
Annette Scholz, Bertil Abrahamsson, Steffen M. Diebold, Edmund Kostewicz, Britta I. Polentarutti, Anna‐Lena Ungell, Jennifer B. Dressman, Influence of hydrodynamics and particle size on the absorption of felodipine in labradors. Pharmaceutical Research. ,vol. 19, pp. 42- 46 ,(2002) , 10.1023/A:1013651215061
F. Javier Moreno, Fred A. Mellon, Martin S. J. Wickham, Andrew R. Bottrill, E. N. Clare Mills, Stability of the major allergen Brazil nut 2S albumin (Ber e 1) to physiologically relevant in vitro gastrointestinal digestion FEBS Journal. ,vol. 272, pp. 341- 352 ,(2005) , 10.1111/J.1742-4658.2004.04472.X
M. Armand, P. Borel, B. Pasquier, C. Dubois, M. Senft, M. Andre, J. Peyrot, J. Salducci, D. Lairon, Physicochemical characteristics of emulsions during fat digestion in human stomach and duodenum American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 271, ,(1996) , 10.1152/AJPGI.1996.271.1.G172
M. Armand, P. Borel, C. Dubois, M. Senft, J. Peyrot, J. Salducci, H. Lafont, D. Lairon, Characterization of emulsions and lipolysis of dietary lipids in the human stomach American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 266, ,(1994) , 10.1152/AJPGI.1994.266.3.G372
Donald D. Van Slyke, ON THE MEASUREMENT OF BUFFER VALUES AND ON THE RELATIONSHIP OF BUFFER VALUE TO THE DISSOCIATION CONSTANT OF THE BUFFER AND THE CONCENTRATION AND REACTION OF THE BUFFER SOLUTION Journal of Biological Chemistry. ,vol. 52, pp. 525- 570 ,(1922) , 10.1016/S0021-9258(18)85845-8