Different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von Hippel-Lindau gene
作者： Iris J H van Vlodrop , Gert G Van den Eynden , Adriaan P de Bruïne , Manon van Engeland , Tania Roskams
关键词:
摘要: Background: von Hippel–Lindau (VHL) inactivation is common in sporadic clear cell renal carcinomas (ccRCC). pVHL part of the ubiquitin ligase complex that targets alpha subunits hypoxia-inducible transcription factor (HIF) for degradation under well-oxygenated conditions. In absence wild-type pVHL, as observed VHL patients and most ccRCCs, constitutive upregulation HIF results transcriptional activation angiogenesis-related genes, such VEGF. Differences angiogenic activity within group ccRCCs were reported strong genotype-phenotype correlations found with disease, raising a question about importance status behaviour tumour progression.
hindawi.com参考文章(53)
E R Maher, F M Richards, A R Webster, N A Affara, A H Prowse, F Resche, S Richard, S Olschwang, Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors. American Journal of Human Genetics. ,vol. 60, pp. 765- 771 ,(1997)
I A Lubensky, J R Gnarra, W M Linehan, Z Zhuang, M M Walther, P Bertheau, Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients American Journal of Pathology. ,vol. 149, pp. 2089- 2094 ,(1996)
Frederic M. Waldman, Michael J. Mihatsch, Joseph C. Presti, Paul Jordan, Guido Sauter, Holger Moch, Niels Buchholz, Genetic Aberrations Detected by Comparative Genomic Hybridization Are Associated with Clinical Outcome in Renal Cell Carcinoma Cancer Research. ,vol. 56, pp. 27- 30 ,(1996)
David A. Walsh, Pathophysiological mechanisms of angiogenesis. Advances in Clinical Chemistry. ,vol. 44, pp. 187- 221 ,(2007) , 10.1016/S0065-2423(07)44006-9
John W. Moore, Naomi Robertson, Christine Blancher, Adrian L. Harris, Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. Cancer Research. ,vol. 61, pp. 7349- 7355 ,(2001)
Eric J. Stanbridge, Stefan Kaluz, Milota Kaluzová, Expression of the Hypoxia Marker Carbonic Anhydrase IX Is Critically Dependent on SP1 Activity. Identification of a Novel Type of Hypoxia-responsive Enhancer Cancer Research. ,vol. 63, pp. 917- 922 ,(2003)
Catherine Morrissey, Alonso Martinez, Malgorzata Zatyka, Angelo Agathanggelou, Sofia Honorio, Dewi Astuti, Neil V Morgan, Holger Moch, Frances M Richards, Takeshi Kishida, Masahiro Yao, Peter Schraml, Farida Latif, Eamonn R Maher, None, Epigenetic Inactivation of the RASSF1A 3p21.3 Tumor Suppressor Gene in Both Clear Cell and Papillary Renal Cell Carcinoma Cancer Research. ,vol. 61, pp. 7277- 7281 ,(2001)
T. Klatte, D. B. Seligson, S. B. Riggs, J. T. Leppert, M. K. Berkman, M. D. Kleid, H. Yu, F. F. Kabbinavar, A. J. Pantuck, A. S. Belldegrun, Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. Clinical Cancer Research. ,vol. 13, pp. 7388- 7393 ,(2007) , 10.1158/1078-0432.CCR-07-0411
Osamu Yoshida, Yuji Chatani, Toshiro Terachi, Yoshiyuki Kakehi, Rika Hoshino, Yusaku Okada, Osamu Ogawa, Hiroya Oka, Masashi Kawaichi, Michiaki Kohno, Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Cancer Research. ,vol. 55, pp. 4182- 4187 ,(1995)
Charles C Wykoff, Christopher W Pugh, Patrick H Maxwell, Adrian L Harris, Peter J Ratcliffe, Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene. ,vol. 19, pp. 6297- 6305 ,(2000) , 10.1038/SJ.ONC.1204012