BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability
作者： Solveig Gretarsdottir , Jorunn E. Eyfjörd , Rut Valgardsdottir , Margret Steinarsdottir , Sigfridur Gudlaugsdottir
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摘要: The products of the BRCA breast cancer susceptibility genes have been implicated in cell cycle control and DNA repair. It has suggested that mutations p53 gene are a necessary step tumorigenesis tumors. We tested samples from 402 patients for germ-line BRCA2 more frequent mutation carriers than they controls. Tumors with either had multiple chromosomal abnormalities, as shown by cytogenetic analysis.
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lsh.is参考文章(20)
Andrew Berchuck, Gudrun Huper, Frank D. Cirisano, P. Andrew Futreal, J. Dirk Iglehart, Jeffrey R. Marks, James P. Vaughn, Cell Cycle Control of BRCA2 Cancer Research. ,vol. 56, pp. 4590- 4594 ,(1996)
Ralph Scully, Junjie Chen, Annemieke Plug, Yonghong Xiao, David Weaver, Jean Feunteun, Terry Ashley, David M Livingston, Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells Cell. ,vol. 88, pp. 265- 275 ,(1997) , 10.1016/S0092-8674(00)81847-4
Yoshio Miki, Toyomasa Katagiri, Fujio Kasumi, Takamasa Yoshimoto, Yusuke Nakamura, Mutation analysis in the BRCA2 gene in primary breast cancers Nature Genetics. ,vol. 13, pp. 245- 247 ,(1996) , 10.1038/NG0696-245
RUT VALGARDSDOTTIR, Laufey Tryggvadóttir, MARGRET STEINARSDOTTIR, KRISTRUN OLAFSDOTTIR, Sigurrós Jónasdóttir, JON G JONASSON, Helga M Ögmundsdóttir, JORUNN E EYFJÖRD, None, Genomic instability and poor prognosis associated with abnormal TP53 in breast carcinomas. Molecular and immunohistochemical analysis. Apmis. ,vol. 105, pp. 121- 130 ,(1997) , 10.1111/J.1699-0463.1997.TB00550.X
Arnold J Levine, p53, the Cellular Gatekeeper for Growth and Division Cell. ,vol. 88, pp. 323- 331 ,(1997) , 10.1016/S0092-8674(00)81871-1
J.G. J�nasson, J. Hrafnkelsson, Nuclear DNA analysis and prognosis in carcinoma of the thyroid gland. A nationwide study in Iceland on carcinomas diagnosed 1955-1990. Virchows Archiv. ,vol. 425, pp. 349- 355 ,(1994) , 10.1007/BF00189572
Steinunn Thorlacius, Gudridur Olafsdottir, Laufey Tryggvadottir, Susan Neuhausen, Jon G Jonasson, Sean V Tavtigian, Hrafn Tulinius, Helga M Ögmundsdottir, Jorunn E Eyfjörd, None, A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nature Genetics. ,vol. 13, pp. 117- 119 ,(1996) , 10.1038/NG0596-117
S Gretarsdottir, L Tryggvadottir, JG Jonasson, H Sigurdsson, K Olafsdottir, BA Agnarsson, H Ogmundsdottir, JE Eyfjörd, TP53 mutation analyses on breast carcinomas: a study of paraffin-embedded archival material British Journal of Cancer. ,vol. 74, pp. 555- 561 ,(1996) , 10.1038/BJC.1996.400
J. V. Rajan, M. Wang, S. T. Marquis, L. A. Chodosh, Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 13078- 13083 ,(1996) , 10.1073/PNAS.93.23.13078
Richard Wooster, Graham Bignell, Jonathan Lancaster, Sally Swift, Sheila Seal, Jonathan Mangion, Nadine Collins, Simon Gregory, Curtis Gumbs, Gos Micklem, Rita Barfoot, Rifat Hamoudi, Sandeep Patel, Patrick Biggs, Yasmin Hashim, Amanda Smith, Frances Connor, Adalgeir Arason, Julius Gudmundsson, David Ficenec, David Kelsell, Deborah Ford, Patricia Tonin, D Timothy Bishop, Nigel K Spurr, Bruce AJ Ponder, Rosalind Eeles, Julian Peto, Peter Devilee, Cees Cornelisse, Henry Lynch, Steven Narod, Gilbert Lenoir, Valdgardur Egilsson, Rosa Bjork Barkadottir, Douglas F Easton, David R Bentley, P Andrew Futreal, Alan Ashworth, Michael R Stratton, None, Identification of the breast cancer susceptibility gene BRCA2 Nature. ,vol. 378, pp. 789- 792 ,(1995) , 10.1038/378789A0