Cell Cycle Control of BRCA2
作者： Andrew Berchuck , Gudrun Huper , Frank D. Cirisano , P. Andrew Futreal , J. Dirk Iglehart
DOI:
关键词: Cell biology 、 DNA synthesis 、 Gene 、 Tumor suppressor gene 、 Cell growth 、 Cell cycle 、 Biology 、 Cell division 、 Cancer research 、 Regulation of gene expression 、 Gene expression
摘要: Identifying the conditions and kinetics of induction BRCA2 gene expression may implicate roles for function tumor suppressor gene. In this study, mRNA is shown to be regulated by cell cycle associated with proliferation in normal tumor-derived breast epithelial cells. Cells arrested G(0) or early G1 contained low levels mRNA. After release into a proliferating state, cells produced maximum late S-phase. Similar control was observed fractions exponentially growing isolated centrifugal elutriation. Expression independent bulk DNA synthesis. addition, up-regulation appeared similar those BRCA1, suggesting that two genes could commonly controlled. These results imply these are utilized during growth have protective role cellular proliferation.
aacrjournals.org参考文章(14)
D T Bishop, D F Easton, D Ford, Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. American Journal of Human Genetics. ,vol. 56, pp. 265- 271 ,(1995)
J R Marks, J Lin, P Hinds, D Miller, A J Levine, Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen. Journal of Virology. ,vol. 63, pp. 790- 797 ,(1989) , 10.1128/JVI.63.2.790-797.1989
S.A. Narod, J.E. Garber, S.A. Smith, P. Devilee, H.T. Lynch, B.A.J. Ponder, B.L. Weber, J.M. Birch, R.B. Barkardottir, D. Ford, An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium. American Journal of Human Genetics. ,vol. 56, pp. 254- 264 ,(1995)
Scott W. Lowe, H.Earl Ruley, Tyler Jacks, David E. Housman, p53-dependent apoptosis modulates the cytotoxicity of anticancer agents Cell. ,vol. 74, pp. 957- 967 ,(1993) , 10.1016/0092-8674(93)90719-7
Marilyn E. Thompson, Roy A. Jensen, Patrice S. Obermiller, David L. Page, Jeffrey T. Holt, Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression Nature Genetics. ,vol. 9, pp. 444- 450 ,(1995) , 10.1038/NG0495-444
Vimla Band, Deborah Zajchowski, Victoria Kulesa, Ruth Sager, None, Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 463- 467 ,(1990) , 10.1073/PNAS.87.1.463
Richard Wooster, Graham Bignell, Jonathan Lancaster, Sally Swift, Sheila Seal, Jonathan Mangion, Nadine Collins, Simon Gregory, Curtis Gumbs, Gos Micklem, Rita Barfoot, Rifat Hamoudi, Sandeep Patel, Patrick Biggs, Yasmin Hashim, Amanda Smith, Frances Connor, Adalgeir Arason, Julius Gudmundsson, David Ficenec, David Kelsell, Deborah Ford, Patricia Tonin, D Timothy Bishop, Nigel K Spurr, Bruce AJ Ponder, Rosalind Eeles, Julian Peto, Peter Devilee, Cees Cornelisse, Henry Lynch, Steven Narod, Gilbert Lenoir, Valdgardur Egilsson, Rosa Bjork Barkadottir, Douglas F Easton, David R Bentley, P Andrew Futreal, Alan Ashworth, Michael R Stratton, None, Identification of the breast cancer susceptibility gene BRCA2 Nature. ,vol. 378, pp. 789- 792 ,(1995) , 10.1038/378789A0
P Andrew Futreal, Qingyun Liu, Donna Shattuck-Eidens, Charles Cochran, Keith Harshman, Sean Tavtigian, L Michelle Bennett, Astrid Haugen-Strano, Jeff Swensen, Yoshio Miki, Ken Eddington, Melody McClure, Cheryl Frye, Jane Weaver-Feldhaus, Wei Ding, Zahra Gholami, Peter Söderkvist, Lori Terry, Suresh Jhanwar, Andrew Berchuck, J Dirk Iglehart, Jeff Marks, Dennis G Ballinger, J Carl Barrett, Mark H Skolnick, Alexander Kamb, Roger Wiseman, BRCA1 mutations in primary breast and ovarian carcinomas Science. ,vol. 266, pp. 120- 122 ,(1994) , 10.1126/SCIENCE.7939630
Y. Chen, C.-F. Chen, D. J. Riley, D. C. Allred, P.-L. Chen, D. Von Hoff, C. K. Osborne, W.-H. Lee, Aberrant Subcellular Localization of BRCA1 in Breast Cancer Science. ,vol. 270, pp. 789- 791 ,(1995) , 10.1126/SCIENCE.270.5237.789
Johnathan M Lancaster, Richard Wooster, Jonathon Mangion, Catherine M Phelan, Charles Cochran, Curtis Gumbs, Sheila Seal, Rita Barfoot, Nadine Collins, Graham Bignell, Sandeep Patel, Rifat Hamoudi, Catharina Larsson, Roger W Wiseman, Andrew Berchuck, J Dirk Iglehart, Jeffrey R Marks, Alan Ashworth, Michael R Stratton, P Andrew Futreal, None, BRCA2 mutations in primary breast and ovarian cancers Nature Genetics. ,vol. 13, pp. 238- 240 ,(1996) , 10.1038/NG0696-238