Quantitation of cerebral ischemic pressor response in dogs.

摘要: Using a surgical technique designed to isolate the cerebral arterial circulation from systemic and extracranial circulations also servomechanism devised prevent blood volume shift between donor dog an experimental dog, dog's brain was perfused at succession of controlled pressures ranging 140 0 mm Hg for purpose investigating quantitatively steady-state response pressure (SAP) stepwise changes perfusion (CPP) flow (CBF). The interrelationships CPP SAP suggested rectangular hyperbolic curve, but this same relationship more clearly demonstrated when plotted against CBF. These findings suggest chemical rather than pressoreceptor basis ischemic response. peak values ΔSAP/ ΔCPP in individual cases varied 11.4 3.1 averaged 7.7; thus found be four or times as powerful carotid sinus pressorecepto...