Immunovirological and Biochemical Changes in Nigerian Patients with Hepatitis B Coinfection on Antiretroviral Therapy

摘要: Hepatitis B virus (HBV) co-infection with HIV is high among Nigerians. Some studies have suggested impaired CD4 recovery coinfected patients compared to the mono infected. This retrospective study of treatment-naive infected was aimed at determining trend changes in CD4+ counts, HIV-RNA and renal liver function tests response combined antiretroviral therapy (CART). A questionnaire utilised extract clinical laboratory data HBV co HIV/AIDS before treatment six, twelve eighteen months CART. Findings were those Relevant statistical instruments used analyse for comparisons means Log10 viral load count using SPSS package 15.0. All levels sig-nificance 5 %. Two thousand five hundred sixty two analysed. Of these, 354(13.8%) HBsAg positive. Majority (63.1%) females. Most recruited on combivir nevirapine. The median negative 104 cells/mm3 (IQR 34 – 171) it significantly higher than positive (91 cells/mm3) (p < 0.05). ALT AST positives, while urea creatinine similar. change from baseline during course similar groups. Similarly, virological responses not different groups various time points. In con-clusion no significant difference rate decline monoin-fected stages therapy.