Internal Structure of 15 nm 3-Helix Micelle Revealed by Small-Angle Neutron Scattering and Coarse-Grained MD Simulation.
作者： JooChuan Ang , Dan Ma , Reidar Lund , Sinan Keten , Ting Xu
DOI: 10.1021/ACS.BIOMAC.6B00986
关键词:
摘要: 3-Helix micelles (3HM) formed by self-assembly of peptide–polymer conjugate amphiphiles have shown promise as a nanocarrier platform due to their long-circulation, deep tumor penetration, selective accumulation in tumor, and ability cross the blood-brain barrier (BBB) for glioblastoma therapy. There is need understand structural contribution high vivo stability performance 3HM. Using deuteration, contrast variation technique small-angle neutron scattering, coarse-grained molecular dynamics simulation, we determined spatial distribution each component within Our results show slightly deformed polyethylene glycol (PEG) conformation micelle that radially offset from its conjugation site toward exterior highly solvated shell. Surprisingly, ∼85 v/v % 3HM water, unusually higher than any micellar based on our knowledge. The result will provide important insights future studies ...
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