Unripe Rubus coreanus Miquel suppresses migration and invasion of human prostate cancer cells by reducing matrix metalloproteinase expression
作者： Yesl Kim , Seung Min Lee , Jung-Hyun Kim
DOI: 10.1080/09168451.2014.921550
关键词:
摘要: Rubus coreanus Miquel (RCM) is used to promote prostate health and has been shown have anti-oxidant anti-carcinogenic activities. However, the effects mechanisms of RCM on cancer metastasis remain unclear. PC-3 DU 145 cells were treated with ethanol or water extract unripe ripe examined for cell invasion, migration, matrix metalloproteinases (MMPs) activity expression. Phosphoinositide 3-kinase (PI3K) Akt activities examined. Unripe extracts exerted significant inhibitory MMPs A reduction in by treatment (UE) was associated expression induction tissue inhibitors (TIMPs) Furthermore, PI3K/Akt diminished UE treatment. In this study, we demonstrated that decreased metastatic potential reducing through suppression of...
oup.com
elsevier.com
sci-hub.se 参考文章(54)
Wen-Sheng Wu, The signaling mechanism of ROS in tumor progression Cancer and Metastasis Reviews. ,vol. 25, pp. 695- 705 ,(2007) , 10.1007/S10555-006-9037-8
F J Vizoso, L O González, M D Corte, J C Rodríguez, J Vázquez, M L Lamelas, S Junquera, A M Merino, J L García-Muñiz, Study of matrix metalloproteinases and their inhibitors in breast cancer. British Journal of Cancer. ,vol. 96, pp. 903- 911 ,(2007) , 10.1038/SJ.BJC.6603666
O Kargiotis, C Chetty, C S Gondi, A J Tsung, D H Dinh, M Gujrati, S S Lakka, A P Kyritsis, J S Rao, Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma Oncogene. ,vol. 27, pp. 4830- 4840 ,(2008) , 10.1038/ONC.2008.122
Kai Kessenbrock, Vicki Plaks, Zena Werb, Matrix Metalloproteinases: Regulators of the Tumor Microenvironment Cell. ,vol. 141, pp. 52- 67 ,(2010) , 10.1016/J.CELL.2010.03.015
Qun Lin, Yi-Jang Lee, Zhong Yun, Differentiation arrest by hypoxia. Journal of Biological Chemistry. ,vol. 281, pp. 30678- 30683 ,(2006) , 10.1074/JBC.C600120200
Sajani S Lakka, Christopher S Gondi, Niranjan Yanamandra, William C Olivero, Dzung H Dinh, Meena Gujrati, Jasti S Rao, Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis Oncogene. ,vol. 23, pp. 4681- 4689 ,(2004) , 10.1038/SJ.ONC.1207616
Jing-Gung Chung, Hsin-Yi Peng, Yu-Chan Chu, You-Miin Hsieh, San-Der Wang, Su-Tze Chou, Anti-invasion and apoptosis induction of chlorella (Chlorella sorokiniana) in Hep G2 human hepatocellular carcinoma cells Journal of Functional Foods. ,vol. 4, pp. 302- 310 ,(2012) , 10.1016/J.JFF.2011.12.008
Myung-Jin Park, Hee-Jin Kwak, Hyung-Chahn Lee, Doo-Hyun Yoo, In-Chul Park, Mi-Suk Kim, Seung-Hoon Lee, Chang Hun Rhee, Seok-Il Hong, None, Nerve growth factor induces endothelial cell invasion and cord formation by promoting matrix metalloproteinase-2 expression through the phosphatidylinositol 3-kinase/Akt signaling pathway and AP-2 transcription factor. Journal of Biological Chemistry. ,vol. 282, pp. 30485- 30496 ,(2007) , 10.1074/JBC.M701081200
Raghu Adya, Bee K. Tan, Anu Punn, Jing Chen, Harpal S. Randeva, Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis Cardiovascular Research. ,vol. 78, pp. 356- 365 ,(2008) , 10.1093/CVR/CVM111
Moran Benhar, David Engelberg, Alexander Levitzki, ROS, stress-activated kinases and stress signaling in cancer. EMBO Reports. ,vol. 3, pp. 420- 425 ,(2002) , 10.1093/EMBO-REPORTS/KVF094