Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

作者: Kai Kessenbrock , Vicki Plaks , Zena Werb

DOI: 10.1016/J.CELL.2010.03.015

关键词: BiologyMatrix metalloproteinaseAngiogenesisTumor microenvironmentCarcinogenesisCell biologyExtracellular matrixTissue homeostasisMatrix metalloproteinase inhibitorMetastasisGeneral Biochemistry, Genetics and Molecular Biology

摘要: … on the tumor microenvironment. … ) enzymes in the microenvironment are present. A key step in regulating MMP activity is the conversion of the zymogen into an active proteolytic enzyme…

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