Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity.
作者： Nicholas Mitsiades , Vassiliki Poulaki , Maria Tsokos , Wei-hsuan Yu , Ivan Stamenkovic
DOI:
关键词: Transfection 、 Fas signaling pathway 、 Cancer research 、 Cytotoxic T cell 、 Biology 、 Fas ligand 、 Tumor necrosis factor alpha 、 Cell 、 Programmed cell death 、 Apoptosis 、 Immunology
摘要: … In our study,MMP-7 expressed in tumor cells was … of MMP-7 protein levels, by transfection of a plasmid carrying the human MMP-7 sequence in antisense orientation sensitized tumor …
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