Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage
作者： M. Gomez , N. Brockdorff
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摘要: DNA replication origins (ORIs) map close to promoter regions in many organisms, including mammals. However, the relationship between initiation of and transcription is not well understood. To address this issue, we have analyzed timing activity several CpG island-associated ORIs on transcriptionally active silent X chromosomes. We find equivalent ORI usage efficiency both alleles at sites that are replicated late inactive chromosome. Thus, contrast its repressive effect transcription, heterochromatin does influence activity. These findings suggest island restricted early development, subsequent gene silencing formation only activation.
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