High spectral and spatial resolution MRI of prostate cancer: a pilot study.

摘要: Purpose High spectral and spatial resolution (HiSS) MRI is a spectroscopic imaging method focusing on water fat resonances that has good diagnostic utility in breast imaging. The purpose of this work was to assess the feasibility potential HiSS for diagnosis prostate cancer. Methods acquired at 3 T from six patients who underwent prostatectomy, yielding train 127 phase-coherent gradient echo (GRE) images. In temporal domain, changes voxel intensity were analyzed linear (R) quadratic (R1, R2) quantifiers signal logarithm decay calculated. three scaling-independent parameters calculated: resonance peak width (PW), relative asymmetry (PRA), distortion ideal Lorentzian shape (PRD). Seven cancer five normal tissue regions interest identified correlation with pathology compared. Results HiSS-derived quantifiers, except R2, showed high reproducibility (coefficients variation, 5%-14%). Spectral domain performed better than receiver operator characteristic areas under curve ranging 0.83 0.91. For parameters, range 0.74 Low absolute values coefficients between monoexponential markers (R, PW) (PRA, PRD) observed (range, 0.23-0.38). Conclusion without an endorectal coil confirmed. Weak well-performing indicates complementary information could be leveraged further improve accuracy.