Tubuloreticular Inclusions in the Absence of Systemic Lupus Erythematosus and HIV Infection: A Report of Three Pediatric Cases.

摘要: Tubuloreticular inclusions (TRIs) are subcellular structures located within the cisternae of endoplasmic reticulum. Formation TRIs has been linked to exposure excess interferon (IFN), either from endogenous or exogenous sources. In renal disease, have most commonly associated with systemic lupus erythematosus (SLE), and human immunodeficiency virus-associated nephropathy (HIVAN). Case reports patients biopsies showing without underlying SLE HIV infrequent in adults, our knowledge none reported children. We report 3 pediatric cases which biopsy showed on electron microscopy infection. The first patient presented at 2 years age nephrotic syndrome failure. His revealed focal segmental glomerulosclerosis TRIs. second 6 months infantile syndrome, his membranous glomerulopathy last 4 acute kidney injury unclear etiology leading chronic disease. Her tubulointerstitial nephritis Despite extensive evaluation all patients, including testing for infection SLE, we could not identify an explain presence conclusion, absence underling remains obscure. propose a possible role IFN triggered by abnormal immune response common viral infections formation injury.