Renal lesions in AIDS: a biopsy and autopsy study.

摘要: We studied renal lesions at biopsy (20 cases) and autopsy (21 among patients with the acquired immune deficiency syndrome (AIDS). Nephrotic concomitant insufficiency was most common indication for biopsy. 85 percent of biopsies showed features HIV associated nephropathy (HIVAN) which include: Focal segmental glomerulosclerosis (FSGS), glomerular collapse mesangial hyperplasia. These changes were always accompanied by tubular microcysts ultrastructurally, tubuloreticular inclusions (TRI) within endothelium often noted. Changes HIVAN also seen in two cases who negative time but positive on repeat testing. Minimal change disease, mesangiocapillary glomerulonephritis diffuse proliferative lupus nephritis other lesions. Autopsy findings (33 percent), necrosis opportunistic infections. conclude that is a distinct clinicopathologic entity may sometimes be first manifestation underlying disease state.