Human Immunodeficiency Virus-associated Nephropathy

摘要: Human immunodeficiency virus-associated nephropathy (HIVAN) is characterized by high-grade proteinuria and rapid progression to end-stage renal disease (ESRD). Despite the large numbers of HIV-infected cases in Asian countries, data on HIVAN this area are limited. We report a 54-year-old Taiwanese man with who presented cytomegalovirus retinitis, insufficiency (serum creatinine, 3.8mg/dL) nephrotic range daily protein loss 10.8g. highly active antiretroviral therapy (HAART) for 31 months, failure developed requiring maintenance hemodialysis. Renal biopsy showed collapsing focal segmental glomerular sclerosis, podocyte proliferation tubulointerstitial nephritis mononuclear cell infiltration. These features were compatible HIVAN. Although hemodialysis was instituted, he died 2 months later due nosocomial pneumonia complicated multiple organ failure. In summary case patient shows that condition may progress ESRD despite successful viral suppression HAART.