Induction of Immune Surveillance of the Dysmorphogenic Lens.

摘要: The lens has been considered to be an immune privileged site not susceptible the processes normally associated with tissue injury and wound repair. However, as greater insight into surveillance process is gained, we have reevaluated concept of privilege. Our studies using N-cadherin lens-specific conditional knockout mouse, N-cadΔlens, show that loss this cell-cell junctional protein leads degeneration, necrosis fibrotic change, postnatally. degeneration induces response resulting in cells populating contribute development fibrosis. Additionally, demonstrate connected lymphatic system, LYVE(+) labeling reaching along suspensory ligaments connect ciliary body, providing a potential mechanism for circulation. Importantly, observe activates throughout eye, including cornea, vitreous humor, retina, suggesting coordinated protective visual system defects component tissue. These can fibrosis often accompanies dysgenesis, consideration understanding organ injury.