The role of integrins in the immune response.

摘要: The integrin is one of at least three different families adhesion molecules. Integrins are heterodimeric cell surface receptors, important for adhesion, migration and cellular interactions immune cells. There 6 subgroups integrins, each defined by a common beta submit (beta 1-beta 6) which shares multiple alpha subunits. Among them the receptors fibronectin, laminin, vitronectin, as well very late activation antigens (VLA 1-6) C11/CD18 complex. role these molecules in response discussed with special focus on 2 integrins (CD11/CD8) their ligand ICAM-1 (CD549).