Autophagic and Apoptotic Pathways as Targets for Chemotherapy in Glioblastoma.

摘要: Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a mean life expectancy less than 15 months. This due in part to high resistance apoptosis moderate resistant autophagic cell death glioblastoma cells, poor therapeutic response conventional therapies. Autophagic represents an alternative mechanism overcome pro-apoptosis-related Nevertheless, induction plays major conceptual role several experimental studies develop novel therapies against tumors. In this review, we outline different components apoptotic pathways explore mechanisms these cells. Finally, discuss drugs clinical preclinical use that interfere survival, proliferation, angiogenesis, migration, invasion, favoring autophagy, or inhibition latter leading death, as well their potential glioma, examine new perspectives promising research field.