Cytotoxicity of ester and ether lysophospholipids on Leishmania donovani promastigotes

摘要: Abstract The cytotoxic activity of four ester lysophospholipids, three ether and two radylglycerols on Leishmania donovani promastigotes was determined by measuring the inhibition cell growth. 1-acyl lysophospholipids reduced growth to 50% controls at concentrations 6.4–10.9 μM. In contrast, 1- O -alkenyl- sn -glycero-3-phosphoethanolamine, -hexadecyl- -glycero-3-phosphocholine, -glycerol already showed a between 2.1 2.8 Moreover, unnatural alkyl lysophospholipid analogue -octadecyl-2-methoxy- -glycero-3-phosphocholine even 10-fold more toxic. Incubations L. with radioactively labelled revealed rapid uptake these compounds their incorporation into cellular lipids non-toxic concentration 1.0 An accumulation in due insufficient metabolism may be cause its effect. sensitivity cells towards found similar that reported for tumor cells.