In search of polymorphic alu insertions with restricted geographic distributions

摘要: Alu elements are transposable that have reached over one million copies in the human genome. Some inserted genome so recently they still polymorphic for insertion presence or absence populations. Recently, there has been an increasing interest using variation studies of population genetic structure and inference individual geographic origin. Currently, this requires a high number loci. Here, we used linker-mediated polymerase chain reaction method to preferentially identify low-frequency various DNA samples with different origins. The candidate loci were subsequently genotyped 18 worldwide populations (approximately 370 individuals), resulting identification two new insertions restricted African ancestry. Our results suggest it may ultimately become possible correctly infer affiliation unknown levels confidence without having genotype as many 100 This is desirable if polymorphisms be evolution forensic applications.