Twenty-five year follow-up of childhood Wilms tumor: A report from the Childhood Cancer Survivor Study†‡

摘要: Background Treatment cures over 90% of children with Wilms tumor (WT) who subsequently risk late morbidity and mortality. This study describes the 25-year outcomes 5-year WT survivors in Childhood Cancer Survivor Study (CCSS). Procedure The CCSS, a multi-institutional retrospective cohort study, assessed (N = 1,256), diagnosed 1970–1986, for chronic health conditions, status, care utilization, socioeconomic subsequent malignant neoplasms (SMNs), mortality compared to US population sibling (N = 4,023). Results The cumulative incidence all severe conditions was 65.4% 24.2% at 25 years. Hazard ratios (HR) were 2.0, 95% confidence interval (CI) 1.8–2.3 grades 1–4 4.7, 95%CI 3.6–6.1 3 4, group. reported more adverse general status than group (prevalence ratio [PR] 1.7; 1.2–2.4), but mental outcome, utilization similar. The SMN 3.0% (95%CI 1.9–4.0%) 6.1% 4.7–7.4%). Radiation exposure increased likelihood congestive heart failure (CHF) (no doxorubicin—HR 6.6; 1.6–28.3; doxorubicin ≤250 mg/m2—HR 13.0; 1.9–89.7; >250 mg/m2—HR 18.3; 3.8–88.2), (standardized [SIR] 9.0; 3.9–17.7 4.9; 1.8–10.6 without doxorubicin) death. Conclusion Long-term treated from 1970 1986 are treatment related years diagnosis. Pediatr Blood 2011; 57: 1210–1216. © 2011 Wiley Periodicals, Inc.