Penicillium aurantiogriseum-induced, persistent renal histopathological changes in rats; an experimental model for Balkan endemic nephropathy competitive with ochratoxin A.

摘要: Renal histopathological changes in rats, caused by food partially moulded a common fungus isolated from an area of nephropathy Yugoslavia, were differentiated into acute and chronic responses. The response to few days on the diet specifically involved necrosis concomitant mitosis proximal tubule cells. More protracted, continuous or intermittent administration nephrotoxic mould led marked karyomegaly same corticomedullary region. phenomenon is more prominent than that induced treatment with ochratoxin A over similar period, raising question putative role such mycotoxins etiology human renal disease.