Periodontal Disease and Decreased Kidney Function in Japanese Elderly

摘要: Background Early detection of decreased kidney function can help prevent the progression disease to failure and cardiovascular events. Potentially significant associations between periodontal have been reported in cross-sectional studies. However, no longitudinal study has performed Japan. The aim this was investigate effect on community-dwelling Japanese elderly. Study Design Retrospective cohort. Setting & Participants Members cohort were drawn from a interdisciplinary aging. Included for analysis 317 participants (166 men, 151 women) aged 75 years 2003. Predictor inflamed surface area (PISA), reflecting amount tissue, calculated each participant. classified quartile groups according PISA, then divided into 2 (highest vs other 3 combined). Outcomes primary outcome function, defined as decrease estimated glomerular filtration rate at follow-up. Measurements Multivariable logistic regression analyses predict basis status, risk factors disease, potentially relevant covariates. Results During 2-year follow-up (2003-2005), 45 (14.2%) developed function. highest PISA associated significantly with greater cumulative incidence (OR, 2.24; 95% CI, 1.05-4.79) than referent group (the quartiles) after adjusting Limitations Extension interpreting findings age is limited. Conclusion These results suggest that may be factor