Periodontal disease, chronic kidney disease and mortality: results from the third National Health and Nutrition Examination Survey.

摘要: Periodontal disease is associated with increased mortality in the general population, however its prognostic significance chronic kidney (CKD) not known. We evaluated joint effect of periodontal and CKD on all-cause cardiovascular mortality. Prospective observational study 10,755 adult participants National Health Nutrition Examination Survey, 1988–1994 (NHANES III). was defined as estimated glomerular filtration rate  4 mm attachment loss ≥ 2 mesial sites or 5 mm pocket depth sites), severe (> 6 mm in ≥ 2 and > 5 mm in ≥ 1 site). All-cause were using Cox proportional hazards models. There 1,813 deaths over a median follow-up 14 years. In multivariate analyses, compared to neither nor CKD, those only had (HR 1.39; 95 % CI, 1.06 - 1.81 1.55; 1.30 - 1.84, respectively). The presence both HR (95 % CI) 2.07 (1.65 - 2.59) for mortality, 2.11 (1.52 - 2.94) found no evidence multiplicativity additivity between CKD. stratified analyses limited individuals (vs. not) adjusted (95 % 1.35 (1.04 - 1.76) all-cause, 1.36 (0.95 - 1.95) These findings confirm well-established association provide new this among