Combined psychotherapy plus benzodiazepines for panic disorder.

摘要: BACKGROUND The efficacy of combining psychotherapy and benzodiazepines for panic disorder is unclear, despite widespread use. OBJECTIVES To examine the combination compared with either treatment alone. SEARCH STRATEGY Randomised trials comparing benzodiazepine therapy alone were identified. Cochrane Depression, Anxiety Neurosis Group Studies References Registers searched. relevant other reviews checked. Experts in field contacted. Additional unpublished data sought from authors original trials. SELECTION CRITERIA Two independently checked records retrieved by searches to identify randomised combined versus monotherapies, among adults disorder. DATA COLLECTION AND ANALYSIS eligibility, assessed quality extracted eligible using a standardised extraction form. primary outcome was "response" based on global judgement. Random-effects meta-analyses conducted, included MAIN RESULTS Three met eligibility criteria. A 16-week behaviour intervention used two trials, 12-week cognitive-behaviour third. Duration follow-up varied, ranging 0 12 months. (total 166 participants) provided (both therapy). No statistically significant differences observed response during (relative risk (RR) 1.25, 95% CI 0.78 2.03, P = 0.35), at end (RR 0.78, 0.45 1.35, 0.37), or last time point, although suggested that might be inferior 0.62, 0.36 1.07, 0.08). One trial (77 found 1.57, 0.83 2.98, 0.17). Although appeared superior 3.39, 1.03 11.21, 0.05) finding only borderline significant, no 7-month 2.31, 0.79 6.74, 0.12). AUTHORS' CONCLUSIONS review established paucity high evidence investigating Currently, there inadequate assess clinical effects patients who are diagnosed