作者: James W Murrough , Sahab Yaqubi , Sehrish Sayed , Dennis S Charney
DOI: 10.1517/14728214.2015.1049996
关键词: Anxiety 、 Novel agents 、 Mechanism (biology) 、 Anxiolytic 、 Basic research 、 Social anxiety 、 Medicine 、 Panic disorder 、 Generalized anxiety disorder 、 Psychiatry
摘要: Introduction: Anxiety disorders are among the most prevalent and disabling psychiatric in United States worldwide. Basic research has provided critical insights into mechanism regulating fear behavior animals a host of animal models have been developed order to screen compounds for anxiolytic properties. Despite this progress, no mechanistically novel agents treatment anxiety come market more than two decades.Areas covered: The current review will provide summary pharmacological approaches examine pharmacotherapeutic pipeline treatments development. related considered herein include panic disorder, social generalized disorder post-traumatic stress disorder. glutamate, neuropeptide endocannabinoid systems show particular promise as future targets drug development.Expert opinion: In face an ever-growing unders...