Decreased undercarboxylated osteocalcin in children with type 2 diabetes mellitus.

摘要: BACKGROUND Osteocalcin (OC) is a bone-specific protein secreted by osteoblasts and often used as bone formation biomarker. OC undergoes post-translational carboxylation to yield carboxylated osteocalcin (Gla-OC) undercarboxylated (uc-OC) molecules. The aim of this study was explore the association between glucose metabolism evaluating OC, ionized cations, markers in children with obesity type 2 diabetes mellitus (DM2). METHODS subjects were nine DM2 [six males, three females; age 15.7±4.1 years; duration disease 3.2±1.2 years], 18 simple [12 six 12.6±4.1 12 controls [eight four 12.3±3.2 years]. Serum Gla-OC uc-OC levels determined using an enzyme-linked immunosorbent assay (ELISA). RESULTS Patients (0.65±0.46 ng/mL), but not (1.11±0.55 had lower than (1.25±0.49 ng/mL). negatively correlated mean serum (r=-0.447, p=0.013) hemoglobin A1c (HbA1c) (r=-0.455, p=0.012) all subjects. alkaline phosphatase (r=0.601, p<0.001) inorganic phosphorus (r=0.686, p<0.001), yet (r=-0.383, p=0.030). Mean magnesium controls. calcium higher obese In subjects, levels. CONCLUSIONS Osteoblast-derived especially uc-OC, may have role pathophysiology being associated blood homeostasis.