The efficacy of combination therapy using adeno-associated virus-mediated co-expression of apoptin and interleukin-24 on hepatocellular carcinoma
作者： Lijie Yuan , Hengyu Zhao , Liqiu Zhang , Xinghan Liu
DOI: 10.1007/S13277-013-0867-Z
关键词:
摘要: Multigene-based combination therapy is an effective practice in cancer gene therapy. Apoptin a chicken anemia virus-derived, p53-independent, Bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis various human tumor cells. Interleukin-24 (IL-24) displays ubiquitous antitumor property and tumor-specific killing activity. Adeno-associated virus (AAV) promising delivery vehicle due its advantage of low pathogenicity long-term expression. In this study, we assessed efficacy using AAV-mediated co-expression apoptin interleukin-24 on hepatocellular carcinoma vitro vivo. Our results showed that IL-24 significantly suppressed growth induced HepG2 cells vitro. Furthermore, combined treatment xenograft nude mice. These data suggest AAV vectors co-express have great potential
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