Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis.
作者： Jinxu Zhou , Hongxiang Wang , Junsheng Chu , Qilin Huang , Guangxu Li
DOI: 10.1002/JCLA.22454
关键词:
摘要: BACKGROUND Recent studies have found circular RNAs (circRNAs) involved in the biological process of cancers. However, little is known about their functional roles glioblastoma. METHODS Human circRNA microarray analysis was performed to screen expression profile circRNAs IDH1 wild-type glioblastoma tissue. The hsa_circ_0008344 and normal brain samples quantified by qRT-PCR. Functional experiments were investigate functions hsa_circ_0008344, including MTT assay, colony formation transwell cell apoptosis assay. RESULTS CircRNA revealed a total 417 abnormally expressed (>1.5-fold, P < .05) tissue compared with adjacent brain. Hsa_circ_0008344, among top differentially circRNAs, significantly upregulated Further vitro showed that knockdown suppressed proliferation, formation, migration, invasion, but increased apoptotic rate. CONCLUSIONS Hsa_circ_0008344 may contribute progression this malignancy.
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