Regulatory Function of Δ6 Desaturase — Key Enzyme of Polyunsaturated Fatty Acid Synthesis
作者： R. R. Brenner
DOI: 10.1007/978-1-4684-3276-3_8
关键词:
摘要: Polyunsaturated fatty acids are synthesized in animals by a sequence of desaturation and elongation reactions which, as we know now, follow special rules. The starting substrates CoA thioesters palmitoleic, oleic, linoleic α linolenic acids. acyl-CoA synthesis is faster than or (Marcel Suzue, 1972). enzymes involved the found either endoplasmic reticulum mitochondria but specificity each group different. microsomal system prefers Δ6 unsaturated hexanoyl whereas mitochondrial medium chain (Podack et al, 1974; Hinsch Seubert, 1975).
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Eckhard R. Podack, Max Lakomek, Gisela Saathoff, Werner Seubert, On the mechanism and control of the malonyl-CoA-dependent chain elongation of fatty acids. Characterization of hexenoyl-CoA reductase from liver and adrenal cortex as a constituent of the microsomal chain elongation. FEBS Journal. ,vol. 45, pp. 13- 23 ,(1974) , 10.1111/J.1432-1033.1974.TB03524.X
A Catalá, A M Nervi, R R Brenner, Separation of a protein factor necessary for the oxidative desaturation of fatty acids in the rat. Journal of Biological Chemistry. ,vol. 250, pp. 7481- 7484 ,(1975) , 10.1016/S0021-9258(19)40969-1
L Mathers, M J Bailey, Enzyme deletions and essential fatty acid metabolism in cultured cells. Journal of Biological Chemistry. ,vol. 250, pp. 1152- 1153 ,(1975) , 10.1016/S0021-9258(19)41903-0
Rodolfo Roberto Brenner, Raúl Omar Peluffo, Effect of Saturated and Unsaturated Fatty Acids on the Desaturation in Vitro of Palmitic, Stearic, Oleic, Linoleic, and Linolenic Acids Journal of Biological Chemistry. ,vol. 241, pp. 5213- 5219 ,(1966) , 10.1016/S0021-9258(18)96419-7
Wilhelm HINSCH, Werner SEUBERT, On the Mechanism of Malonyl‐CoA‐Independent Fatty‐Acid Synthesis FEBS Journal. ,vol. 53, pp. 437- 447 ,(1975) , 10.1111/J.1432-1033.1975.TB04084.X
John T. Bernert, Howard Sprecher, Studies to determine the role rates of chain elongation and desaturation play in regulating the unsaturated fatty acid composition of rat liver lipids Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 398, pp. 354- 363 ,(1975) , 10.1016/0005-2760(75)90186-1
David Ullman, Howard Sprecher, An in vitro studyof the effects of linoleic, eicosa-8,11,14-trienoic and arachidonic acids on the desaturation of stearic, oleic and eicosa-8,11-dienoic acid Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 248, pp. 61- 70 ,(1971) , 10.1016/0005-2760(71)90075-0
Rodolfo R. Brenner, Angel Catala, Effect of ATP on the microsomal desaturation of unsaturated fatty acids. Lipids. ,vol. 6, pp. 873- 881 ,(1971) , 10.1007/BF02531168
Sara M. Actis Dato, Angel Catala, Rodolfo R. Brenner, Circadian rhythm of fatty acid desaturation in mouse liver Lipids. ,vol. 8, pp. 1- 6 ,(1973) , 10.1007/BF02533231
Rodolfo R. Brenner, Raúl O. Peluffo, Regulation of unsaturated fatty acids biosynthesis 1. Effect of unsaturated fatty acid of 18 carbons on the microsomal desaturation of linoleic acid into γ-linolenic acid Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 176, pp. 471- 479 ,(1969) , 10.1016/0005-2760(69)90214-8