Comparison of the effects of albumin 5%, hydroxyethyl starch 130/0.4 6%, and Ringer's lactate on blood loss and coagulation after cardiac surgery

摘要: Abstract Background Infusion of 5% human albumin (HA) and 6% hydroxyethyl starch 130/0.4 (HES) during cardiac surgery expand circulating volume to a greater extent than crystalloids would be suitable for restrictive fluid therapy regimen. However, HA HES may affect blood coagulation could contribute increased transfusion requirements. Methods We randomly assigned 240 patients undergoing elective receive up 50 ml kg−1 day−1 either HA, HES, or Ringer's lactate (RL) as the main infusion perioperatively. Study solutions were supplied in identical bottles dressed opaque covers. The primary outcome was chest tube drainage over 24 h. Blood transfusions, thromboelastometry variables, perioperative balance, renal function, mortality, intensive care unit, hospital stay also assessed. Results median cumulative loss not different between groups (HA: 835, HES: 700, RL: 670 ml). 35% RL required products, compared with 62% 64% (HES group; P=0.0003). Significantly, more study solution had administered group colloid groups. Total balance least positive [6.2 (2.5) litre] [7.4 (3.0) [8.3 (2.8) (P Conclusions Despite equal from drains, both colloids interfered produced haemodilution, which associated products crystalloid use only.