Pathophysiology of Idiopathic Detrusor Instability and Detrusor Hyper-reflexia
作者： R. B. KINDER , A. R. MUNDY
DOI: 10.1111/J.1464-410X.1987.TB05031.X
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摘要: Muscle strips from urodynamically normal bladders and exhibiting idiopathic detrusor instability or hyper-reflexia were compared under isometric conditions in an organ bath. Spontaneous contractions developed more often unstable hyper-reflexic muscle of greater amplitude, frequency basal tension. Electrical field stimulation caused a frequency-dependent contraction which was largely abolished by both tetrodotoxin (TTX) atropine all three types. Comparison their response curves demonstrated significantly sensitivity than that to low frequencies. Acetylcholine dose-related contractile There no significant differences between the dose muscle, those muscle. The results suggest pathophysiology involuntary is common this related disorder intrinsic neuromodulatory mechanism within
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