From white spots to stem cells: the role of the Kit receptor in mammalian development

作者: Roger A. Fleischman

DOI: 10.1016/0168-9525(93)90015-A

关键词:

摘要: The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development postnatal life. This review summarizes the genetic evidence implicating its ligand, Steel factor, in control of stem cell proliferation, migration survival, with emphasis on mutations human mouse genes.

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