Influence of age on the response to Streptococcus pneumoniae vaccine in patients with recurrent infections and normal immunoglobulin concentrations.

摘要: Abstract Background: A deficient antibody response to polysaccharide antigens is determined by measuring the 23-valent pneumococcal vaccine. However, diagnosis of this specific deficiency hampered lack sufficient data and standardized testing polysaccharides. Methods: All patients evaluated in our allergy/immunology clinic for recurrent respiratory infections between 1995 1997 without immunoglobulin, IgG subclass, or other known primary secondary immunodeficiency were included analysis. antipneumococcal serotypes 1, 3, 4, 6B, 9V, 14, 18C, 19F, 23F a modified ELISA protocol. An adequate an individual serotype was arbitrarily defined as postimmunization titer 1.3 μg/ml greater at least four times baseline value. Results: total 113 fulfilling criteria inclusion analysis divided into five age groups. The geometric means preimmunization titers all increased with age. For concentrations, there sharp increase concentrations adults comparison pediatric groups ranging from 7 months 16 years. Similarly, number which also Conclusion: We conclude that definition what constitutes immunization needs further definition. It clear, however, has important influence on intensity most Correlation studies different subclasses, functional studies, protection against mucosal invasive are progress, these should contribute refined normal response. availability method measurement antibodies relevant step toward goal. (J Allergy Clin Immunol 1998;102:215-21.)