Receptors for Transferrin on Human Neutrophils
作者： A. Maneva , B. Taleva
DOI: 10.1080/13102818.2009.10818467
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摘要: ABSTRACTThe kinetics of 59FeTf binding to the neutrophil membrane receptors was evaluated. Results showed that polymorphonuclear leucocytes (PMN) possess not only for lactoferrin, but also transferrin. Receptor experiments biphasic patterns with two peaks saturation: 16% and 30% specific cell receptors. The Scatchards analysis evaluated types sites: One—with high affinity low capacity: Ka1 = 9.88 × 108 M−1and 40 300 receptors/cell, (y1 9.92 - 0.182.x, n=2, r= -1, p<0.001), second—with Ka2 12.54 109 M−1 129 000 receptors/cell (y2 4.04 0.21.x, n =4, r -0.999, p<0.001). It is probably transferrin on have function ensure a controlled pathway Fe2+ transfer prevent an iron overload, thus accomplish antioxidative protection membrane.
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