Entry of iron into cells: a new role for the transferrin receptor in modulating iron release from transferrin.

摘要: The versatile chemistry of iron and the noxious reactions this essential metal may promote have compelled iron-dependent organisms to form specific iron-binding proteins maintain in soluble, nontoxic, accessible for cellular needs. A variety pathways can be traversed by gain access cells, some available all others restricted specialized cells. Of these pathways, most important widely functioning is uptake from transferrin a receptor-mediated process. By regulating expression receptor, including neurons, assured an adequate supply while guarding against toxic excess. However, receptor functions not only capturing iron-bearing transferrin, but also restraining release at cell surface, where iron-catalyzed lipid peroxidation threat, facilitating acidified endosomes ensure safe efficient delivery cell.