Functional Liver Recovery After Bariatric Surgery—a Prospective Cohort Study with the LiMAx Test
作者： Patrick H. Alizai , Janica Wendl , Anjali A. Roeth , Christian D. Klink , Tom Luedde
DOI: 10.1007/S11695-015-1664-0
关键词:
摘要: Bariatric surgery provides long-term weight loss and improvement of obesity-associated diseases such as nonalcoholic steatohepatitis (NASH). Histologic NASH has been reported in some studies after bariatric surgery. This study was designed to assess the liver function obese patients well its recovery with a noninvasive test method. In prospective cohort from October 2011 May 2014, morbidly individuals receiving were investigated for functional (n = 34). Liver determined by LiMAx (enzymatic capacity cytochrome P450 1A2) preoperatively, 6 12 months postoperatively. biopsy specimens obtained 18 participants classified according fatty disease (NAFLD) activity score (NAS). The mean age 44 years, body mass index (BMI) 52 kg/m2. percent excess BMI (%EBMIL) 53 % 6 months 68 % 1 year. Mean increased significantly 255 μg/kg/h preoperative 324 μg/kg/h 342 μg/kg/h 12 months. A negative correlation observed between %EBMIL alteration first 6 months. Finally, median NAS showed capacity. leads significant liver. An initial marked may negatively influence recovery.
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N. Assy, G.Y. Minuk, Liver regeneration: methods for monitoring and their applications Journal of Hepatology. ,vol. 26, pp. 945- 952 ,(1997) , 10.1016/S0168-8278(97)80266-8
Zobair M. Younossi, Francesco Gorreta, Janus P. Ong, Karen Schlauch, Luca Del Giacco, Hazem Elariny, Amy Van Meter, Abraham Younoszai, Zachary Goodman, Anna Baranova, Alan Christensen, Geraldine Grant, Vikas Chandhoke, Hepatic gene expression in patients with obesity-related non-alcoholic steatohepatitis. Liver International. ,vol. 25, pp. 760- 771 ,(2005) , 10.1111/J.1478-3231.2005.01117.X
Pouneh Mofrad, Melissa J Contos, Mahmadul Haque, Carol Sargeant, Robert A Fisher, Velimir A Luketic, Richard K Sterling, Mitchell L Shiffman, Richard T Stravitz, Arun J Sanyal, Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values Hepatology. ,vol. 37, pp. 1286- 1292 ,(2003) , 10.1053/JHEP.2003.50229
T. Longerich, C. Flechtenmacher, P. Schirmacher, Maß und Zahl in der Hepatopathologie Pathologe. ,vol. 29, pp. 15- 26 ,(2008) , 10.1007/S00292-007-0963-1
Edward Lebovics, Jonah Rubin, Non-alcoholic fatty liver disease (NAFLD): why you should care, when you should worry, what you should do. Diabetes-metabolism Research and Reviews. ,vol. 27, pp. 419- 424 ,(2011) , 10.1002/DMRR.1198
Shivakumar Chitturi, Geoffrey C. Farrell, Etiopathogenesis of Nonalcoholic Steatohepatitis Seminars in Liver Disease. ,vol. 21, pp. 027- 042 ,(2001) , 10.1055/S-2001-12927
Sherif Saadeh, Zobair M. Younossi, Erick M. Remer, Terry Gramlich, Janus P. Ong, Maja Hurley, Kevin D. Mullen, James N. Cooper, Michael J. Sheridan, The utility of radiological imaging in nonalcoholic fatty liver disease Gastroenterology. ,vol. 123, pp. 745- 750 ,(2002) , 10.1053/GAST.2002.35354
Kevin B. Barker, Nicole A. Palekar, Steven P. Bowers, Joel E. Goldberg, Joseph P. Pulcini, Stephen A. Harrison, Non-Alcoholic Steatohepatitis: Effect of Roux-en-Y Gastric Bypass Surgery The American Journal of Gastroenterology. ,vol. 101, pp. 368- 373 ,(2006) , 10.1111/J.1572-0241.2006.00419.X
Charlotte Rabl, Guilherme Campos, The impact of bariatric surgery on nonalcoholic steatohepatitis. Seminars in Liver Disease. ,vol. 32, pp. 080- 091 ,(2012) , 10.1055/S-0032-1306428
Philippe Mathurin, Antoine Hollebecque, Laurent Arnalsteen, David Buob, Emmanuelle Leteurtre, Robert Caiazzo, Marie Pigeyre, Hélène Verkindt, Sébastien Dharancy, Alexandre Louvet, Monique Romon, François Pattou, Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease Gastroenterology. ,vol. 137, pp. 532- 540 ,(2009) , 10.1053/J.GASTRO.2009.04.052