Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease

摘要: Background & Aims Severe obesity is implicated in development of nonalcoholic fatty liver disease (NAFLD). Bariatric surgery induces weight loss and increases survival time obese patients, but little known about its effects on damage. We performed a 5-year prospective study to evaluate fibrosis steatosis (NASH) severely patients after bariatric surgery. Methods was 381 patients. Clinical biological data, along with biopsies, were collected before at 1 5 years Results Five surgery, levels increased significantly, 95.7% maintained score ≤ F1. The percentage decreased from 37.4% 16%, the NAFLD 1.97 1, ballooning 0.2 0.1. Inflammation remained unchanged. probable or definite NASH significantly over years, 27.4% 14.2%. kinetics insulin resistance (IR) paralleled that ballooning; greatest improvements occurred within first year sustained later. Steatosis more frequently refractory IR profile. In multivariate analysis, profile independently predicted persistence Conclusions for severe obesity, almost all had low NAFLD, whereas slightly increased. closely linked IR; long-term could be by early improvement IR.