Expression of CD44 in human lung tumors.

摘要: CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan. Here we report novel biomarker non-small cell lung tumors, squamous metaplasia of lung, and activated type II pneumocytes. We have examined expression in 12 human tumor lines 23 fixed, paraffin-embedded cancers. transcription translation consistently high among tumors (5 5 lines, 10 14 tumors) but rare small (1 6 0 9 tumors). In normal was confined to surface bronchial basal cells alveolar macrophages. Squamous showed strong immunoreactivity. Resting pneumocytes were largely negative rows active, surfactant-secreting had significant amounts located on lateral surfaces adjacent cells. The correlation between phenotype further demonstrated studies cultured cancer line induced exhibit characteristics by infection with v-Ha-ras. Following ras gen insertion, these 40-fold increase expression. detected throughout predominantly "standard" rather than "variant" species. Taken together, results suggest protein expressed metaplasia, addition, transcriptionally following differentiation oncogene. fact immunohistochemistry can be used discriminate types makes valuable new marker neoplasia.