LIN28/LIN28B: An emerging oncogenic driver in cancer stem cells
作者： Jianbiao Zhou , Siok-Bian Ng , Wee-Joo Chng
DOI: 10.1016/J.BIOCEL.2013.02.006
关键词:
摘要: LIN28 (LIN28A) is a reprogramming factor and conserved RNA-binding protein. LIN28B the only homolog of in humans, sharing structure certain function. LIN28/LIN28B has been identified to be overexpressed wide range solid tumors hematological malignancies. Blockage let-7 miRNA biogensis subsequent derepression target genes by play important roles cancer progression metastasis. We will first provide an overview gene protein structures, followed summary studies that showed their aberrant expression primary human cancers relevant clinical significance with emphasis on formation stem cells. Next, we highlight current knowledge regulators molecular mechanisms LIN28/LIN28B-mediated oncogenesis. The potential medical applications for targeting also discussed this review.
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