Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients.
作者： YOSHIHIKO SHIBAYAMA , TAKESHI KONDO , HIROKI OHYA , SHIN-ICHI FUJISAWA , TAKANORI TESHIMA
DOI: 10.3892/OR.2015.3839
关键词:
摘要: MicroRNAs (miRs) have been shown to negatively regulate gene expression by binding mRNAs, and they play an important role in various physiological processes ma lignancies. A previous study identified mature miR-126-3p as onco-microRNA that is generated from the pre-microRNA, miR-126. Although miR-126 also generates miR-126-5p, its function less clear. In present study, relationship between miR-126-5p/3p levels overall survival 109 patients with acute myeloid leukemia (AML) who received intensive therapy were evaluated. Higher above median value of correlated a poorer survival. The hazard ratio 95% confidence intervals (95% CI) for higher group relative lower 2.098 CI: 1.075–4.228) 1.958 1.001–3.927), respectively. An interaction was not observed ratios miR-126-5p (p=0.73). Transfection mimic into AML cell line, KG-1, resulted decrease sensitivity cytarabin level Klotho mRNA well elevation phosphorylation Akt. results demonstrated prognosis. Furthermore, elevated
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