miR-223 decreases cell proliferation and enhances cell apoptosis in acute myeloid leukemia via targeting FBXW7.

摘要: The expression of microRNA-223 (miR-233) has been investigated in various types cancer. However, to the best our knowledge, and function miR-223 acute myeloid leukemia (AML) remains be elucidated. was measured by reverse transcription-quantitative polymerase chain reaction. Following transfection with miR-223, cell viability assays, apoptosis western blot analysis luciferase assays were conducted AML lines. In present study, it initially observed that downregulated patients compared healthy subjects. It also demonstrated inhibited proliferation enhanced Additionally, study provided evidence may directly target F-box WD repeat domain containing 7 AML. identification candidate genes provide an understanding potential mechanisms underlying development conclusion, results have therapeutic implications exploited for further treatment