Tea Flavonoids: Bioavailability In Vivo and Effects on Cell Signaling Pathways In Vitro

摘要: The elucidation of the potential health benefits tea beverage continues to be a focus research in many laboratories. Beneficial effects have been particularly evident animal tumorigenesis models, with green and black frequently demonstrating similar effectivity. Human data are now emerging support beneficial role for cardiovascular disease, but respect cancer risk at various sites remain inconclusive. constituent flavonoids known potent antioxidants, although this may major factor explaining their biological activity, it appears that gallated particular (e.g., epigallocatechin gallate theaflavins) impact on wide range molecular targets influence cell growth more specifically pathways such as those involving angiogenesis. Data pharmacokinetic properties flavonoids, primarily catechins therefore related most closely tea, provided indications plasma levels circulating forms expected humans following consumption. structural complexity thearubigins, has hindered efforts describe bioavailability perform mechanistic studies. Recent studies theaflavins factor-, nuclear factor-kappaB-, stress-mediated signal transductions described review, where possible relation vivo. These indicate relevant both atherosclerosis often observed flavonoid could realistically encountered However, need performed using (methylated, sulfated, glucuronidated conjugates) species Such studies, combined further human epidemiological interventional data, should ultimately elucidate full health.