Cell-metal interaction studied by cytotoxic and FT-IR spectroscopic methods.

摘要: The main purpose of this work is to investigate the possibility utilizing both a classical biological method test cytotoxicity and physical measurement procedure as FT-IR spectroscopy study interaction between cells lines heavy metals. Jurkart, lymphocyte cell line, was treated with cadmium chloride, oxide organic germanium compound named Ge-oxy-132. utilized value metal concentration allows us obtain significant results methods all In fact by using lower values any effect revealed after treatment germanium. simultaneous measurements experimental procedures are here reported for first time show that, while cytotoxic effects two compounds confirmed, reveals very different interesting Jurkart cells. behaviour upon uptake or different: CdO CdCl(2) determines proteins denaturation lipids oxidation in until death, these processes not Ge-oxy-132 treatment.